Medications which can induce or increases feelings of anxiety,
agitation, akathisia, aggression, hostility, irritability, and/or disinhibition could lead toward self-directed or outwardly directed violence in a pre-disposed individual. It is reasonable from a psychological perspective to understand how a medication which can induce or increases feelings of anxiety, agitation, akathisia, aggression, hostility, irritability, and/or disinhibition could lead toward self-directed or outwardly directed violence in a pre-disposed individual. I have examined many specific cases of potential medication-induced suicidal ideation, prepared case-specific and general causation expert reports, and given depositions and in-trial testimony for these types of cases.
I have had direct experience with my own patients, some of whom have developed medication-induced increases in aggitation, aggression, suicidal and homicidal ideation.
Some specific examples of my writings in this area :
Marks, DH. Evaluation of Medical Causation, in Drug Injury: Liability, Analysis and Prevention, Second Edition, Chapter 10. O’Donnell JT editor. L&J Publications, 2005
Marks DH, Adineh M, Wang B, Gupta S. Use of fMRI to Predict Psychiatric Adverse Effects of Interferon Treatment for Hepatitis C. Neuropsychiatric Disease and Treatment. 2007:3(5) 655-667.
Marks DH. Depression Leading to Suicide As An Adverse Effect of Metoclopramide. Internet Journal of Gastroenterology [peer-reviewed serial on the Internet]. 2007. Volume 5 Number 2.
Marks DH, Breggin PR, Braslow D. Homicidal Ideation Causally Related To Therapeutic Medications. Ethical Human Psychology and Psychiatry, accepted 2008. Simultaneously published by agreement in The International Journal of Risk and Safety in Medicine, Volume 20 (4),2008, pp 231-240.
Marks DH, Adineh M, Gupta S. MR Imaging of Drug-Induced Suicidal Ideation, Internet J Radiology [peer-reviewed serial on the Internet], 9(1). 2008. http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijra/vol9n1/suicidal.xml
Marks DH and Milby J. Interferon and Risk for Drug-Seeking Behavior, Internet Journal of Pain, Symptom Control and Palliative Care [peer-reviewed serial on the Internet]. 2009, 6(2). http://www.ispub.com/ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijpsp/vol6n2/ifn.xml
Member of the Editorial Board, The International Journal of Risk & Safety in Medicine
5/10/02 Neuropsychiatric Effects of Accutane, Depression, Seizures, Psychosis & Suicide, Conference, Birmingham, AL.
7/10/02 Medication Errors and Drug Adverse Effects, Medical Staff Meeting, Brookwood Medical Center, Birmingham, AL.
10/4/02 Neuropsychiatric Effects of SSRI Drugs. Seizures, Psychosis & Suicide, Philadelphia, PA
2/2/04 Adverse Effects of SSRI Drugs, FDA Psychopharmacologic Drugs Advisory Committee, Pediatric Subcommittee of the Anti-Infective Drugs Advisory Committee
3/2/04 Medication Adverse Effects. Scientific Session, Medical Association of the State of Alabama.
3/22/06 Application of fMRI to Understand Neuropsychopharmacologic Effects of Peg-Interferon alpha-2 & Their Treatment, presentation to Dept Pharmacology, Rush Univ Med Ctr, Chicago
5/10/06 Hepatitis C Virus Infection: Diagnosis and Treatment, Jefferson County Health Department, Birmingham, AL.
6/21/07 Hepatitis C Virus Infection: Diagnosis and Treatment, Brookwood Medical Center, Birmingham, AL
10/14/07 Use of Functional MR Imaging to Predict Psychiatric Adverse Effects of Therapeutic Medications, American College of Legal Medicine, Chicago.
4/18/08 MR Imaging of Drug-Induced Suicidal Ideation; poster presentation at the 2008 annual meeting of the American Association of Suicidology, Boston. MA